20 articles
Specific mutational signatures accumulate linearly with age in normal tissues, offering a new window into why cancer risk rises exponentially as we get older.
Large study reveals cancer survivors have higher biological age than cancer-free individuals, with strongest mortality predictions from epigenetic clocks.
Cambridge scientists engineer a nanoprobe that detects therapy-induced senescence non-invasively through a simple urine colorimetric test.
A major review reveals how inflammaging and immunosenescence synergistically drive colorectal cancer in older adults, reshaping the tumor microenvironment.
New research reveals young and elderly cervical cancer patients have completely different molecular signatures requiring age-specific treatments.
New research reveals senescent cells have both harmful and protective roles, pushing anti-aging science toward targeted removal strategies.
Dive deep into the molecular machinery of genomic instability — from telomere-driven crisis states and epigenetic remodeling at break sites to cutting-edge therapeutic strategies targeting DNA repair fidelity in aging and cancer.
Scientists discover that maintaining proteostasis in tumor-infiltrating lymphocytes prevents exhaustion and boosts immunotherapy outcomes.
A comprehensive review reveals how the senescence secretome suppresses tumors early but drives progression, resistance, and metastasis chronically.
Scientists found drugs that kill senescent 'zombie cells' by blocking their key survival protein, shrinking tumors in mice.
New research reveals how tiny cellular packages from aging cells might be engineered to deliver targeted cancer treatments.
New review reveals how cancer biology has fundamentally transformed our understanding of mitochondrial plasticity and its implications beyond oncology.
New research shows that the level of RAS oncogene activity determines whether cells become senescent or tumorigenic — a key cancer-prevention insight.
New review reveals how senescent cells both prevent and promote cancer, opening therapeutic opportunities.
Scientists discover that 3' UTRs of mRNAs actively guide protein folding during translation, controlling activity of key cancer and aging regulators.
Comprehensive comparison of Stereo-seq, Visium HD, CosMx, and Xenium platforms reveals key performance differences for cancer research applications.
Scientists discover that enhancing protein cleanup in immune cells prevents exhaustion and dramatically improves cancer immunity.
New research reveals how selenium deficiency drives liver cancer progression through neutrophil aging and immune suppression.
New research reveals how progenitor cells drive the transition from benign to malignant cancer, offering potential intervention targets.
Fibrotic tissue stiffness activates a cascade that recruits immune cells and generates DNA-damaging aldehydes, linking dense breast tissue to cancer risk.
