20 articles
Researchers analyzed 2,911 proteins in 50,506 people to create a frailty score that predicts disease risk and biological aging.
New study shows DunedinPACE aging biomarker can predict who will develop metabolic syndrome years in advance, outperforming other epigenetic clocks.
Large NHANES study reveals metabolic syndrome causes measurable acceleration in epigenetic aging clocks, offering new targets for intervention.
Second-generation epigenetic clocks show strong associations with metabolic syndrome and type 2 diabetes risk prediction.
A molecular-level deep dive into AGE formation kinetics, RAGE isoforms, downstream transcriptional networks, and evidence-based interventions — for those who want the full mechanistic picture.
New cryo-EM structures reveal how LYCHOS protein senses cholesterol levels to regulate mTORC1 signaling, offering drug targets for aging.
A noninvasive 13-variable score reveals how fast your liver is aging — and accelerated liver aging raises mortality risk by up to 85%.
Three NIH-funded studies this week tackle metabolic decline, cardiac risk, and brain tumors — all with aging implications.
Large study reveals specific blood proteins can identify who will die from heart disease a decade before death occurs.
Large study reveals how gut microbe proteins shift with aging and contribute to diabetes and metabolic disorders.
A 6-month AI-driven personalized diet intervention cut BMI by 33% and reduced biological age by 8 years in morbidly obese patients.
Explore how sirtuins use NAD+ as a molecular switch to regulate aging, DNA repair, and metabolism — and what happens when this system breaks down.
A new review reframes magnesium as a master regulator of mitochondrial energy, metabolic disease, and biological aging.
Go beyond the basics and explore the biochemical mechanisms behind glycation — from the Maillard reaction cascade to RAGE signaling and tissue cross-linking — to understand why AGEs are central to aging and metabolic disease.
Mice lacking the HDAC9 gene gained less fat with age, accumulated fewer senescent cells, and showed improved mitochondrial respiration in adipose tissue.
Researchers discover how disrupted circadian rhythms in fat cells impair mitochondrial function, leading to metabolic syndrome.
A new framework redefines age-related insulin resistance as a systemic collapse of metabolic resilience spanning muscle, fat, brain, and more.
A comprehensive review reveals how obesity and aging converge through shared inflammatory biomarkers, accelerating disease risk in the elderly.
New research reveals how a key cellular protein prevents ferroptosis, a type of cell death implicated in aging and age-related diseases.
Three new NIH-funded findings tackle metabolic aging, cardiovascular risk, and a surprising hormonal brake on brain tumors.
