How Your Heart Ages and What Science Can Do to Slow It Down
A 2025 review maps the molecular mechanisms driving cardiovascular aging—from inflammaging to ECM remodeling—and outlines emerging therapies.
20 articles
A 2025 review maps the molecular mechanisms driving cardiovascular aging—from inflammaging to ECM remodeling—and outlines emerging therapies.
In obese middle-aged mice, reducing dietary protein—without cutting calories—reversed cardiac inflammation and remodeling via AMPK-ULK1 mitophagy.
A comprehensive review reveals how inflammaging—the fusion of aging and inflammation—fuels cardiovascular disease through senescence, mitochondrial dysfunction, and gut dysbiosis.
Advanced spatial mapping shows vascular regions drive cardiac aging through inflammation and senescence accumulation.
A landmark Circulation review reveals how aging blood vessels accelerate systemic decline — and outlines emerging therapies to stop it.
New research in Circulation explores how cardiac biomarkers may serve as early predictors of skeletal muscle deterioration.
A 2025 review maps the molecular drivers of cardiac aging and evaluates drugs, CRISPR, stem cells, and lifestyle as countermeasures.
New research reveals specific proteins that explain why lower socioeconomic status increases cardiovascular disease risk in older adults.
A novel CTSL–Notch1–CUX1 pathway drives endothelial senescence and atherosclerotic plaque buildup, revealing fresh drug targets.
Scientists reveal CFTR protein prevents cardiomyocyte senescence by reducing mitochondrial oxidative stress via a newly discovered deubiquitination pathway.
Mendelian randomization links circulating inflammatory proteins to retinal microvascular changes, heart disease risk, and lifespan — establishing causal direction.
Scientists map a precise molecular chain linking falling NAD levels to lysosomal dysfunction, cardiolipin loss, and age-related heart failure — and show NAD restoration can reverse it.
New review reveals how telomere shortening drives cardiovascular aging and identifies promising therapeutic targets for heart health.
New biomarker could identify dementia risk decades before symptoms appear, enabling earlier intervention strategies.
Dr. Jamnadas reveals how cooking methods and food choices create AGEs that damage your body and accelerate aging at the cellular level.
German study explored how lifelong inflammatory burden contributes to cardiac aging by measuring heart rate variability changes.
Scientists discover how a molecular switch in blood vessel cells accelerates aging and plaque formation, revealing new therapeutic targets.
Dr. Jamnadas reveals which foods can protect against AGEs, the hidden compounds in our diet that speed up aging and disease.
Dr. Jamnadas reveals how common cooking techniques create AGEs that accelerate aging and increase disease risk.
A new review examines how drugs that clear senescent cells could transform treatment of age-related cardiovascular disease.