20 articles
A new framework proposes organ-specific biological clocks using multi-omics data to better predict disease onset and aging trajectories.
Specific mutational signatures accumulate linearly with age in normal tissues, offering a new window into why cancer risk rises exponentially as we get older.
A new Cell Metabolism review from NIH identifies how ECM stiffening, poor blood flow, and mitochondrial failure lock tissues into accelerating decline.
A landmark review reveals how sustained glucocorticoid exposure drives aging biology — and what can be done about it.
A new review maps the bidirectional crosstalk between gut microbiota and cellular senescence driving multi-organ degeneration.
A landmark review argues neurodegeneration is driven by interacting misfolded proteins, not single culprits — reshaping diagnosis and treatment.
A new review reframes magnesium as a master regulator of mitochondrial energy, metabolic disease, and biological aging.
Scientists propose space environments as unique models for studying accelerated aging mechanisms and potential interventions.
A new framework redefines age-related insulin resistance as a systemic collapse of metabolic resilience spanning muscle, fat, brain, and more.
Researchers outline innovative approaches to speed up drug development for age-related diseases and longevity interventions.
Age-related shifts in intestinal T cell populations may silently erode gut barrier function, accelerating the chronic inflammation that drives aging diseases.
Senescent T cells fuel psoriasis, eczema, and rosacea through toxic secretions. New therapies may finally break the cycle.
New research reveals how people over 100 maintain youthful immune systems despite chronic inflammation, offering insights for healthy aging.
Expert reviews compare leading senolytic and NAD+ supplement brands on ingredients, evidence quality, and value.
Aging disrupts gut microbiota and mTOR signaling, crippling vaccine responses — but targeted interventions may reverse this.
A landmark review maps the structural, genetic, and molecular changes that erode lung function with age — and why reversing them matters.
New review reveals how senescent cells both prevent and promote cancer, opening therapeutic opportunities.
A product review breaks down the evidence tiers for four popular longevity supplements and rates the best commercial stacks.
Expert reviews of top CGM platforms reveal genuine metabolic insights — but no proof they extend lifespan in healthy adults.
Expert reviews rank fisetin and quercetin as top senolytics, with spermidine and resveratrol as supporting players in longevity supplement stacks.
