61 articles
Small molecule AA-20 clears protein aggregates and lipid droplets, extending C. elegans lifespan through a novel mTOR-independent autophagy pathway.
Uremic toxins impair mitochondrial cleanup in osteocytes, revealing new drug targets to protect bones in chronic kidney disease.
A novel SQSTM1-mediated selective autophagy pathway degrades p16 and p21, reducing cellular senescence in degenerative mitral valve disease.
A new study reveals that too much or too little Wnt signaling disrupts cilia formation, with mTOR inhibition rescuing the defect.
A comprehensive 2025 review maps the molecular and cellular mechanisms driving immune aging, from SASP to epigenetic drift.
A single 30-minute ultrasound session reverses 15 hallmarks of senescence in vitro and boosts healthspan in aged mice — no drugs required.
A landmark multi-omic study shows GLP-1 receptor agonists like semaglutide broadly reverse age-related molecular changes in aging mice.
A 2025 review maps the molecular drivers of cardiac aging and evaluates drugs, CRISPR, stem cells, and lifestyle as countermeasures.
From a massive family study of centenarians to a paradigm shift in how aging is measured, longevity science is evolving fast.
A major review identifies nine common drugs—including metformin, aspirin, and dasatinib—with promising anti-aging mechanisms targeting shared biological pathways.
A major meta-analysis of 911 effect sizes finds rapamycin, but not metformin, replicates the lifespan benefits of dietary restriction in vertebrates.
A murine arthritis study finds rapamycin suppresses neuropeptide Y, linking cellular senescence to joint inflammation via SASP cytokines.
