20 articles
A deep mechanistic exploration of how hypothalamic IKKβ/NF-κB signaling, htNSC exosomal communication, and multi-axis hormonal dysregulation drive systemic aging — plus cutting-edge therapeutic strategies.
A µ-opioid receptor superagonist shows strong analgesic potency in preclinical work while minimizing addiction, respiratory depression, and other classic opioid harms.
Go beneath the surface to explore how NF-κB signaling, IKKβ activation, and hypothalamic stem cell decline drive whole-body aging — and which interventions can slow the process.
LINE-1 retrotransposons act as alternative gene promoters in human stem cells, and silencing them shrinks cerebral organoids.
Dive into the molecular machinery behind lifelong brain health — from BDNF-TrkB signaling cascades and adult hippocampal neurogenesis to glymphatic amyloid clearance and cutting-edge interventions including senolytics, GLP-1 agonists, and transcranial stimulation.
SOMCL-668 improved memory and reduced brain damage in Alzheimer's mice by targeting sigma-1 receptors and protective pathways.
Stanford-led framework defines the five core components of medical digital twins and maps how AI plus mechanistic modeling can create living patient simulations.
Advanced 5-second sleep monitoring uncovers previously hidden sleep disruption patterns that correlate with disease severity.
A completed pilot trial tests whether 2g/day of a novel carnosine formulation can restore neuromuscular function and quality of life in MS patients.
MIT researchers decode how C. elegans brains coordinate sensory input with motor actions during navigation using sequential neural firing patterns.
Researchers assembled data from 200 studies to map how human brain cortex develops, revealing new insights for neurological health.
New framework reveals obesity as chronic disease driven by neuroendocrine dysfunction, not just lifestyle choices.
Scientists built human amygdala-like brain organoids that model stress circuitry, uncovering a novel cortisol-driven mechanism tied to primate-specific gene regulation.
A truncated orexin-A fragment outperforms full-length hypocretin-1 in distinguishing narcolepsy type 1 patients from controls.
New research shows Hericium erinaceus can force neuroblastoma cells to differentiate into mature neurons while stopping their cancerous growth.
A 6,000+ organoid study links specific cellular phenotypes to microcephaly, polymicrogyria, epilepsy, and intellectual disability with 92% classification accuracy.
The SenNet atlas reveals where aging cells accumulate in human tissues, opening new doors for senolytic therapies and healthspan extension.
Master the molecular machinery of sleep-dependent brain clearance, dissect melatonin's chronobiological role, and apply evidence-based protocols — from CBT-I to pharmacological aids — to engineer restorative sleep for longevity.
Researchers develop holistic NEST approach treating infant sleep issues through nurturing care rather than isolation methods.
A landmark review reveals the ANS regulates metabolism, immunity, and aging — far beyond simple fight-or-flight control.
