20 articles
A new partnership brings standardized spermidine into US clinical settings, shifting longevity science from shelves to physician-guided care.
Go beyond the basics and explore the precise molecular mechanisms by which polyamines slow cellular aging — from autophagy induction to epigenetic regulation and cardiovascular protection.
New research reveals spermidine supplements and low-protein diets independently protect against brain aging in fruit flies.
Master the full systems-level view of polyamine biology — from biosynthetic flux control and post-translational modifications to clinical trial design and emerging therapeutic strategies.
Discover the fascinating world of polyamines — natural compounds found in food and made by your body that researchers are linking to longer, healthier lives.
Salmon-derived PDRN prevents degradation of the longevity protein SIRT1 by reducing autophagy in UV- and oxidative stress-damaged skin cells.
Combining the Rhodiola compound salidroside with mesenchymal stem cells restores ovarian function by blocking iron-driven cell death in a rat model.
Dihydromyricetin, found in vine tea, acts as a dual senotherapeutic—suppressing SASP in fibroblasts and eliminating senescent microglia in Alzheimer's mice.
New research shows pyrroloquinoline quinone improves egg maturation and embryo development in animal models.
Delphinidin, a natural anthocyanin, prevented microglial senescence via AMPK/SIRT1 signaling, reducing amyloid plaques and restoring cognition in AD mice.
Natural compound improves egg quality and pregnancy outcomes in aging mice, offering hope for age-related infertility treatment.
SS-31 dramatically improves survival and brain recovery after cardiac arrest by blocking iron-driven cell death in microglia via the Sesn2 pathway.
Dasatinib and quercetin nanoparticles improve egg quality and fertility in aging mouse ovaries by clearing senescent cells.
Systematic review finds NMN enhances mitochondrial function and reduces oxidative stress in oocytes across multiple animal models.
NMN supplementation improved oocyte quality in mice with chemotherapy damage and older women, offering hope for fertility preservation.
Three days of GDF11 infusion post-injury preserved pericytes, protected the blood-spinal cord barrier, and improved functional recovery in mice.
A comprehensive review reveals that human spermatogonial stem cells operate via primate-specific rules, reshaping models for male fertility preservation.
Scientists discover that raising cytosolic NADPH in endothelial cells—via G6PD or folic acid—reverses hallmarks of vascular aging in mice.
Study shows nicotinamide mononucleotide supplementation protects ovarian reserve and egg quality during cyclophosphamide chemotherapy in mice.
Echinacoside restores spindle integrity, cuts oxidative stress, and boosts mitochondrial function in aging oocytes through the GJA1/SIRT1 pathway.
