Spermine Acts as Molecular Glue to Clear Alzheimer's and Parkinson's Proteins
New research reveals how spermine promotes protein condensation and autophagy to combat neurodegeneration in lab models.
20 articles
New research reveals how spermine promotes protein condensation and autophagy to combat neurodegeneration in lab models.
A new partnership brings standardized spermidine into US clinical settings, shifting longevity science from shelves to physician-guided care.
Go beyond the basics and explore the precise molecular mechanisms by which polyamines slow cellular aging — from autophagy induction to epigenetic regulation and cardiovascular protection.
Oxford researchers tested whether spermidine could rejuvenate aging immune systems and improve vaccination effectiveness in adults over 65.
A double-blind RCT finds daily spermidine supplementation reverses immune senescence markers and boosts vaccine antibody responses in adults over 65.
Novel KH-1 supplement containing spermidine and probiotics tested for autophagy stimulation and glucose control in 42 prediabetic participants.
New research reveals spermidine supplements and low-protein diets independently protect against brain aging in fruit flies.
New research reveals how polyamine molecules regulate cellular aging and may offer promising anti-aging interventions.
New research reveals how these two popular longevity supplements target different cellular pathways for anti-aging benefits.
Master the full systems-level view of polyamine biology — from biosynthetic flux control and post-translational modifications to clinical trial design and emerging therapeutic strategies.
Discover the fascinating world of polyamines — natural compounds found in food and made by your body that researchers are linking to longer, healthier lives.
Salmon-derived PDRN prevents degradation of the longevity protein SIRT1 by reducing autophagy in UV- and oxidative stress-damaged skin cells.
Combining the Rhodiola compound salidroside with mesenchymal stem cells restores ovarian function by blocking iron-driven cell death in a rat model.
NAD+ precursor supplementation restored fertility markers and improved embryo development in diabetes-induced reproductive dysfunction.
Dihydromyricetin, found in vine tea, acts as a dual senotherapeutic—suppressing SASP in fibroblasts and eliminating senescent microglia in Alzheimer's mice.
Pyrroloquinoline quinone at 5 μM improved porcine oocyte maturation, reduced ROS, and raised blastocyst formation rates in a new lab study.
New research shows pyrroloquinoline quinone improves egg maturation and embryo development in animal models.
New research reveals how polyamines flip from supporting healthy aging to turbocharging tumor growth through different cellular pathways.
Study shows nicotinamide mononucleotide (NMN) restores NAD+ levels and reverses declining oocyte quality in polycystic ovary syndrome.
50 nm polystyrene nanoplastics accumulate in mouse testes, degrading sperm quality and triggering iron-dependent cell death through a newly identified mitochondrial pathway.