20 articles
Natural flavonoid fisetin activates mitophagy and xenophagy pathways to restrict intracellular Salmonella growth in immune cells.
Senescent cells drive cyst growth in ADPKD, and targeting them with senolytics or the aldose reductase inhibitor epalrestat delays disease progression.
Scientists used CRISPR to find SPART, a human gene that restricts a whole family of dangerous flaviviruses including Zika and dengue.
Structural biology uncovers the exact amino acid motif causing species-specific drug failures, enabling transgenic mouse models for better P2X7 drug testing.
Demethyleneberberine, derived from traditional Chinese medicine, significantly reduced lung scarring by targeting NLRP3 inflammasome and EMT in mice.
Mice lacking the PERP apoptosis gene develop faulty thymic immune screening, accumulating self-reactive T-cells that trigger arthritis as they age.
Researchers uncover how the STING immune pathway triggers mitochondrial fragmentation and DNA release, fueling deadly lung inflammation in sepsis.
A new veterinary sedative is contaminating the illegal fentanyl supply, posing novel overdose risks that standard treatments may not reverse.
A murine arthritis study finds rapamycin suppresses neuropeptide Y, linking cellular senescence to joint inflammation via SASP cytokines.
A phase 1/2 trial finds low-dose oral NMN safely raises platelet counts in steroid-refractory ITP via a novel immunometabolic mechanism.
Scientists reveal how a measles antiviral also blocks Nipah virus and use structural insights to engineer more potent next-generation inhibitors.
New research reveals how immune cells use cysteine for both antioxidant defense and energy production, with major implications for cancer treatment.
A completed Phase 3 trial tests placental MSC secretome injections against placebo in 60 GvHD patients at an Iranian hospital.
A mechanistic deep-dive into cutting-edge anti-inflammaging interventions — from senolytic pharmacology and precision cytokine targeting to partial reprogramming strategies that aim to restore youthful immune homeostasis.
GlaxoSmithKline tests a novel NS5B inhibitor across four dose groups in chronic HCV patients, evaluating safety and short-term antiviral activity.
New research reveals how SIRT2 regulates T cell responses, potentially improving cancer immunotherapy and immune function.
A pilot study finds one 30-minute PAPIMI electromagnetic field session significantly reduced pain scores and raised parasympathetic HRV markers in chronic musculoskeletal pain patients.
A deep mechanistic exploration of neutrophil extracellular trap biology in the context of aging — from PAD4 citrullination dynamics and gasdermin-driven release to clinical immunopathology and next-generation therapeutic targets.
A major Cochrane network meta-analysis protocol aims to compare and rank interventions for preeclampsia prevention before 17 weeks gestation.
Scientists identify key mechanism that determines why some immune thrombocytopenia patients maintain remission after stopping treatment.
