20 articles
50 nm polystyrene nanoplastics accumulate in mouse testes, degrading sperm quality and triggering iron-dependent cell death through a newly identified mitochondrial pathway.
Master the salvage, de novo, and Preiss-Handler pathways that maintain NAD+ levels and drive longevity interventions.
Maastricht University investigated whether NA, NAM, and tryptophan together could restore mitochondrial function in physically compromised older adults.
Explore how sirtuins use NAD+ as a molecular switch to regulate aging, DNA repair, and metabolism — and what happens when this system breaks down.
A Phase IIa trial explores whether the HIF-PHI drug daprodustat can safely replace EPO injections in hemodialysis patients with anemia.
A new ESRRA-ATG5 axis links mitochondrial recycling to arginine metabolism, and a plant polyphenol activates it to protect diabetic kidneys.
Brief weekly PEMF exposures increased quail embryo weight by ~20%, body length by ~15%, and upregulated key oxidative muscle genes.
Breakthrough study reveals sepiapterin dramatically outperforms existing PKU therapy, offering hope for better metabolic control.
A completed trial investigates whether replenishing glutathione precursors can reverse metabolic dysfunction in elderly adults.
Deep dive into sirtuin enzymatic mechanisms, substrate specificity, and their role in metabolic reprogramming through NAD+-dependent deacetylation cascades.
New research reveals pulsed electromagnetic field therapy selectively enhances ATP-linked mitochondrial respiration, pointing to a specific cellular energy mechanism.
New research reveals how a key cellular protein prevents ferroptosis, a type of cell death implicated in aging and age-related diseases.
Veterinary sedative medetomidine increasingly adulterates street fentanyl, causing severe cardiac effects and heightened overdose risk.
A steroid hormone activates receptor GPR56 to block ferroptosis, a form of iron-driven cell death linked to liver disease.
Discover how sirtuins act as your cellular repair crew and learn practical ways to boost these powerful longevity proteins naturally.
Discover how NAD+ powers your cells and why this crucial molecule decreases as we age, plus practical ways to support healthy levels.
New study shows DunedinPACE aging biomarker can predict who will develop metabolic syndrome years in advance, outperforming other epigenetic clocks.
Daily anthocyanin supplementation helped over half of prediabetic participants return to normal glucose tolerance in just 12 weeks.
New research shows melatonin supplementation during IVF can prevent obesity and glucose problems in offspring by restoring liver function.
New research shows dietary methionine enhances kidney function to clear harmful inflammatory molecules from the bloodstream.
