20 articles
Three days of GDF11 infusion post-injury preserved pericytes, protected the blood-spinal cord barrier, and improved functional recovery in mice.
Researchers erased imprinting marks in mouse sperm using dCas9-TET1, then traced how methylation partially recovered — fingering H3K9me3 as the key mediator.
Researchers found that inhibiting LSD1 enzyme increases SEC23A protein levels, potentially treating congenital anemia.
A Cell study reveals why ~50% of fertilized human eggs arrest, identifying two independent molecular culprits at different developmental stages.
Explore the molecular mechanisms of cellular senescence and how p16/p21 pathways drive SASP production, plus cutting-edge senolytic drug targets.
ProcyanidinC1, a natural senolytic, selectively eliminates senescent cells in diabetic skin, dramatically improving wound healing in mouse models.
Psychological stress impairs hematopoietic stem cells by suppressing brain regions, depleting gut microbiome-derived spermidine, and triggering ferroptosis.
New research uncovers how MECP2 protein regulates DNA damage repair in brain cells, offering insights into neurological health.
Researchers used prime editing to introduce and then correct a de novo GDF11 nonsense mutation, revealing Golgi stress and broad transcriptomic dysregulation.
Scientists discover how histone methyltransferase Setd8 maintains retinal stem cells, offering insights into developmental biology.
A short-term drug combo rejuvenates aged mesenchymal stem cells, boosting proliferation and reducing inflammatory markers in vitro.
A novel anti-swelling hydrogel loaded with dasatinib, quercetin, and nucleus pulposus exosomes clears senescent cells and restores disc integrity in rats and goats.
A landmark Cell study reveals p53 actively enables chemical reprogramming to pluripotency, overturning assumptions and boosting regenerative medicine safety.
A senolytic pairing of dasatinib and quercetin cleared senescent cells at the tendon-bone junction, dramatically improving repair strength in aged rats.
Researchers improve ADAR-based RNA editing precision using guide RNAs modeled on highly edited natural substrates.
Dasatinib + quercetin clears senescent kidney cells, restores anti-aging protein Klotho, and reverses transcriptional aging across multiple renal cell types.
Researchers used AI screening to identify bavisant, a histamine receptor drug, as a potential therapy to repair nerve damage in MS.
Enhanced stem cells reduced inflammation and improved bladder function in rats with nerve damage.
A pharmacological cocktail transiently activates reprogramming genes in senescent endothelial cells, restoring function and improving blood flow in aged mice.
A new mitochondrial epigenetic editor silences aging-linked genes without altering DNA sequence, opening doors to programmable longevity interventions.
