20 articles
Blocking mTOR forces cancer cells to rewire cholesterol uptake and transport, revealing new drug targets when combined with rapamycin.
Discover how sirtuins act as your cellular repair crew and learn practical ways to boost these powerful longevity proteins naturally.
New research reveals how mitochondrial metabolism regulates dendritic cells' ability to activate anti-tumor immunity.
Mice lacking the HDAC9 gene gained less fat with age, accumulated fewer senescent cells, and showed improved mitochondrial respiration in adipose tissue.
Explore how sirtuins use NAD+ as a molecular switch to regulate aging, DNA repair, and metabolism โ and what happens when this system breaks down.
New research reveals how glucose metabolism directly controls fat tissue expansion through a novel epigenetic pathway involving JMJD1A.
Scientists discover how PDAP1 protein reprograms liver cells to burn less fat and make more, driving hepatocellular carcinoma progression.
A deep mechanistic exploration of how ectopic lipid accumulation, mitochondrial dysfunction, mTOR-IRS1 feedback, and inflammatory crosstalk converge to drive age-related insulin resistance โ plus emerging therapeutic strategies.
New cryo-EM structures reveal how LYCHOS protein senses cholesterol levels to regulate mTORC1 signaling, offering drug targets for aging.
Deep dive into the master regulatory pathways controlling mitochondrial biogenesis, quality control, and cellular energy homeostasis through PGC-1ฮฑ coordination.
Deep dive into sirtuin enzymatic mechanisms, substrate specificity, and their role in metabolic reprogramming through NAD+-dependent deacetylation cascades.
A newly discovered lipid recycling loop driven by DGAT enzymes generates significant body heat โ and it's been hiding in plain sight.
New research identifies choline kinase alpha as a key driver of diabetic retinopathy and microvascular dysfunction.
A newly identified protein shields the liver from alcohol injury by bridging mitochondria and fat droplets to enhance fatty acid oxidation.
Go deeper into how AMPK detects energy stress, activates upstream kinases, and coordinates metabolism, autophagy, and longevity pathways at the molecular level.
Researchers found a dual-target approach that selectively destroys the most treatment-resistant form of acute myeloid leukemia.
Master the advanced molecular architecture of AMPK โ from isoform-specific signaling and spatial compartmentalization to emerging pharmacological strategies targeting the energy sensor at the heart of longevity biology.
A new ESRRA-ATG5 axis links mitochondrial recycling to arginine metabolism, and a plant polyphenol activates it to protect diabetic kidneys.
Three new NIH-funded findings tackle metabolic aging, cardiovascular risk, and a surprising hormonal brake on brain tumors.
A molecular-level deep dive into AGE formation kinetics, RAGE isoforms, downstream transcriptional networks, and evidence-based interventions โ for those who want the full mechanistic picture.
