20 articles
A newly identified molecular chain reaction links tau aggregates to neuronal death, revealing ZBP1 as a promising therapeutic target in Alzheimer's disease.
Scientists find that TDP43 protein regulates DNA repair systems, linking neurodegeneration to cancer when repair goes wrong.
New research reveals how TSC2 mutations suppress translation of autism and epilepsy genes, offering potential therapeutic targets.
A deep mechanistic exploration of how hypothalamic IKKฮฒ/NF-ฮบB signaling, htNSC exosomal communication, and multi-axis hormonal dysregulation drive systemic aging โ plus cutting-edge therapeutic strategies.
A chromatin-remodeling gene called SMARCAD1 controls tau levels โ and switching it off could be a new therapeutic target for Alzheimer's.
New research reveals how mammalian brains evolved specialized DNA repair mechanisms to support expansion of upper cortical layers.
LINE-1 retrotransposons act as alternative gene promoters in human stem cells, and silencing them shrinks cerebral organoids.
A GeneReviews update details how activating MTOR variants cause a rare overgrowth-intellectual disability syndrome, with early rapamycin trials showing promise.
Dr. Rhonda Patrick reveals how sulforaphane, omega-3s, vitamin D, and magnesium trigger cellular stress responses that enhance longevity.
New research identifies FTL1 protein as key driver of brain aging. Reducing it restored memory and neural connections in mice.
New research identifies ZNF280A as essential for DNA repair and links its deletion to 22q11.2 distal deletion syndrome features.
New research reveals how TDP-43 protein causes energy failure in motor neurons, pointing to potential metabolic therapies for ALS.
New study identifies KCTD20 gene suppression as a potential therapeutic target for clearing harmful tau proteins in neurodegenerative diseases.
A master autophagy regulator drops with age and in AD patients โ restoring it in mice clears amyloid, reduces tau, and rescues cognition.
Scientists discover tanycytes help clear toxic tau from the brain. When damaged, these cells may allow Alzheimer's progression.
New brain organoid study shows autophagy-boosting compounds can clear harmful tau proteins and rescue synapses in Alzheimer's disease models.
UCSF scientist reveals how engineered T-cells and CRISPR are transforming cancer treatment and prevention strategies.
OSK gene therapy targeting engram neurons restored memory to youthful levels in aged mice and Alzheimer's models, reversing senescence hallmarks.
Go beneath the surface to explore how NF-ฮบB signaling, IKKฮฒ activation, and hypothalamic stem cell decline drive whole-body aging โ and which interventions can slow the process.
New research reveals how glucose availability directs brain cell proliferation via a metabolic-epigenetic axis, with implications for MS and brain repair.
