20 articles
New research reveals stem cells from urine contain telomerase activity that could combat aging by maintaining telomeres and rejuvenating tissues.
Dihydrotestosterone treatment restored heart function in aging mice by activating DNA repair mechanisms and reducing inflammation.
New research reveals how LMNA gene mutations cause premature aging in heart cells by shortening protective telomeres.
A rigorous mechanistic deep-dive into the molecular logic of partial reprogramming — from chromatin dynamics and epigenetic clock reversal to in vivo delivery strategies, oncogenic risks, and the path to clinical translation.
New research reveals how activating HDAC5 enzyme accelerates wound healing, offering hope for diabetic and chronic wounds.
Go beyond the basics and explore the precise molecular mechanisms by which Yamanaka factors remodel the epigenome, silence cell identity, and unlock pluripotency — with implications for partial reprogramming therapies.
Researchers developed a method to rejuvenate aging stem cells, extending their lifespan beyond 100 days while preserving function.
Researchers erased imprinting marks in mouse sperm using dCas9-TET1, then traced how methylation partially recovered — fingering H3K9me3 as the key mediator.
A landmark Cell study reveals p53 actively enables chemical reprogramming to pluripotency, overturning assumptions and boosting regenerative medicine safety.
Tumor-infiltrating lymphocyte therapies are emerging as a powerful cancer treatment. Here's what the science says and why it matters for longevity.
A new class of cancer drugs targets replication stress — a core vulnerability in tumor cells — potentially opening a long-sought therapeutic window.
Dive deep into partial reprogramming, niche remodeling, senolytics, and cutting-edge clinical therapies — the molecular toolkit for reversing stem cell aging.
Explore how stem cell decline contributes to aging and what cutting-edge research reveals about maintaining our regenerative potential.
Researchers used prime editing to introduce and then correct a de novo GDF11 nonsense mutation, revealing Golgi stress and broad transcriptomic dysregulation.
Activating three Yamanaka factors — OCT4, SOX2, and KLF4 — appears to reverse epigenetic aging in human eye cells, marking a milestone in rejuvenation medicine.
Scientists discover how histone methyltransferase Setd8 maintains retinal stem cells, offering insights into developmental biology.
Explore the molecular mechanisms of cellular senescence and how p16/p21 pathways drive SASP production, plus cutting-edge senolytic drug targets.
Scientists discover how a uniquely human genetic enhancer drives brain development, creating more neurons and thicker cortex in animal models.
PARP inhibitors have transformed cancer treatment, but resistance and toxicity are emerging as serious limits to their long-term effectiveness.
A landmark review reveals the molecular pathways driving thymic self-repair after injury, with major implications for aging immunity.
