20 articles
Researchers identify N4BP2, the enzyme behind chromothripsis - a genetic catastrophe that helps one in four cancers rapidly evolve and resist treatment.
RZ-001 earns rare RMAT designation for hepatocellular carcinoma, signaling RNA editing's rise as a precise, programmable cancer treatment.
When the DNA-repair gene EXO1 is overproduced, it damages DNA instead of fixing it—exposing a hidden vulnerability in multiple cancers.
Researchers discovered how to restore tumor-killing power in worn-out immune cells by switching off just two genes.
Scientists find that TDP43 protein regulates DNA repair systems, linking neurodegeneration to cancer when repair goes wrong.
A protein called HOXD13 drives skin cancer growth and shields tumors from immune cells — disabling it could unlock powerful new treatments.
Tumor-infiltrating lymphocyte therapies are emerging as a powerful cancer treatment. Here's what the science says and why it matters for longevity.
Clearing zombie cells then restoring stem cell activity produced far greater lifespan gains than either approach alone.
A newly discovered CRISPR tool called Cas12a2 selectively destroys cancer cells by detecting their unique RNA signals, cutting tumor volume by 50% in mice.
A new MIT-led therapy uses mRNA nanoparticles to rewire immune cells from within, achieving complete tumor regression in most treated mice.
A small molecule called UNI418 shuts down cancer cells' DNA repair machinery, making drug-resistant tumors vulnerable to treatment again.
A new class of cancer drugs targets replication stress — a core vulnerability in tumor cells — potentially opening a long-sought therapeutic window.
Adding talazoparib to enzalutamide dramatically improves survival odds for men with metastatic prostate cancer and DNA repair gene mutations.
Disabling the NFIL3 protein prevents CAR T cell exhaustion, boosting tumor-fighting power in animal models of hard-to-treat cancers.
A new Cas12a2-based system identifies cancerous or virus-infected cells by their RNA and destroys them — tested across multiple human cancer lines.
A new wave of biotechs is targeting aging as a root cause, using encapsulated cells and gene therapy to restore lost proteins and reverse decline.
When tumors hide from killer T cells, they accidentally expose themselves to helper T cells that trigger a lethal iron-driven cell death process.
A single FGF21 gene injection in aging mice extended median lifespan by 20%, reversing fat gain, inflammation, and organ decline.
A dual therapy clearing senescent cells and restoring stem cell function dramatically extended mouse lifespan in a new preclinical study.
Scientists boosted a protein that dampens chronic inflammation, and older mice grew stronger, more energetic, and had healthier bones.
