Cellular Senescence Shows Promise as Cancer Treatment Target
New review reveals how senescent cells both prevent and promote cancer, opening therapeutic opportunities.
20 articles
New review reveals how senescent cells both prevent and promote cancer, opening therapeutic opportunities.
A new review reveals how epithelial-to-mesenchymal transition fuels tumor invasion, immune evasion, and drug resistance through dynamic, reversible states.
A new Cell Metabolism review from NIH identifies how ECM stiffening, poor blood flow, and mitochondrial failure lock tissues into accelerating decline.
Specific mutational signatures accumulate linearly with age in normal tissues, offering a new window into why cancer risk rises exponentially as we get older.
A major review in Nature Medicine explores how CAR cell therapies may achieve deep immune 'reset' in autoimmune diseases by depleting pathogenic B cells.
Senescent T cells fuel psoriasis, eczema, and rosacea through toxic secretions. New therapies may finally break the cycle.
New research reveals how people over 100 maintain youthful immune systems despite chronic inflammation, offering insights for healthy aging.
New research reveals how tumors might hijack sympathetic nervous system signals to boost their metabolism and proliferation.
A translational review outlines how stem cell technologies may finally make hepatocyte-based liver therapies clinically viable.
A landmark review reveals how sustained glucocorticoid exposure drives aging biology โ and what can be done about it.
New review reveals how advanced genomics tools are revolutionizing cancer diagnosis and therapy development.
A landmark review maps the three pillars of modern lineage tracing and how they're reshaping our understanding of cell fate decisions.
Researchers outline innovative approaches to speed up drug development for age-related diseases and longevity interventions.
A new review reframes magnesium as a master regulator of mitochondrial energy, metabolic disease, and biological aging.
New computational advances help identify which tumor peptides trigger immune responses, potentially revolutionizing personalized cancer therapy.
A new review reframes how myeloid cells fuel or fight tumors, pointing to plasticity โ not just cell diversity โ as the core therapeutic target.
Expert reviews compare leading senolytic and NAD+ supplement brands on ingredients, evidence quality, and value.
A new perspective in Nature Cancer outlines how genetically engineered bacteria can target and destroy tumors from within.
New review explores how 3D organoids and bioengineered niches are revolutionizing tumor research and treatment development.
A new review maps the bidirectional crosstalk between gut microbiota and cellular senescence driving multi-organ degeneration.