Brain Tumor Telomere Patterns Reveal New Treatment Targets
Study of 183 brain tumor samples reveals distinct telomere maintenance patterns that could guide personalized cancer therapy.
20 articles
Study of 183 brain tumor samples reveals distinct telomere maintenance patterns that could guide personalized cancer therapy.
Dive deep into the molecular machinery of genomic instability โ from telomere-driven crisis states and epigenetic remodeling at break sites to cutting-edge therapeutic strategies targeting DNA repair fidelity in aging and cancer.
END-seq reveals ALT-positive cancer telomeres share canonical 5โฒ ATC termini with normal cells, but harbor uniquely abundant single-stranded DNA regions.
A landmark WGS study of 1,804 myeloid neoplasia patients uncovers how telomere length varies by mutation type and cancer subtype.
A 10-week supervised strength program targets chronic inflammation and self-efficacy in long-term allogeneic HCT survivors.
New nanotechnology selectively destroys cancer cell mitochondria, making tumors more vulnerable to T cell attacks across multiple cancer types.
New research reveals senescent cells have both harmful and protective roles, pushing anti-aging science toward targeted removal strategies.
Scientists discover that maintaining proteostasis in tumor-infiltrating lymphocytes prevents exhaustion and boosts immunotherapy outcomes.
New review reveals how senescent cells both prevent and promote cancer, opening therapeutic opportunities.
Scientists identify a mitochondria-proteasome-haem pathway that silences immune cells โ and show bortezomib can fix it in CAR-T therapy.
Researchers explored whether cancer-derived cell-free DNA and telomere maintenance mutations could serve as early warning biomarkers in soft tissue sarcoma patients.
Study maps hepatitis B virus DNA integration sites in liver cancer, revealing distinct patterns that predict patient outcomes.
Scientists used precise gene editing to enhance CAR-T cell therapy, creating more effective and persistent cancer treatments.
Scientists develop advanced drug delivery methods to detect and eliminate harmful senescent tumor cells that promote cancer spread.
Scientists discover how to reprogram cancer cells into harmless, non-dividing cells by targeting a nuclear enzyme pathway.
Scientists discover KLHL6 protein prevents immune cell dysfunction in tumors, offering new target for cancer immunotherapy.
Novel treatment triggers ferroptosis in cancer cells while activating immune responses that further enhance cancer cell death.
New review reveals how targeting mitochondria in cancer cells could overcome immunotherapy resistance and enhance anti-tumor responses.
A 73-patient study finds PD-L1 expression and TERT mutations identify high-grade thyroid cancers most likely to benefit from checkpoint inhibitor therapy.
Scientists develop innovative immunotherapy that reprograms multiple immune cell types to attack cancer while reducing side effects.