20 articles
A 2026 review maps the molecular architecture of telomerase across four model organisms, illuminating cancer and aging disease mechanisms.
Engineered telomerase RNA (eTERC) lengthens telomeres in patient iPSCs and blood stem cells, offering a potential therapy for telomere biology disorders.
New research reveals hTERT can prevent cellular aging through telomere compaction rather than lengthening, challenging current understanding.
A comprehensive review reveals how cancer exploits telomere maintenance and DNA repair pathways—and how new therapies aim to shut them down.
A 2025 study shows epitalon lengthens telomeres in normal cells via telomerase and in cancer cells via ALT, offering new anti-aging insights.
New review reveals how telomere shortening drives cardiovascular aging and identifies promising therapeutic targets for heart health.
A sweeping review maps how telomerase inhibitors evolved from lab concept to approved drug, spotlighting imetelstat's landmark approval in blood cancers.
A new yeast study reveals telomeres can self-regulate their length independently via Sir4-telomerase recruitment, reshaping our understanding of aging.
Study of 183 brain tumor samples reveals distinct telomere maintenance patterns that could guide personalized cancer therapy.
Deep dive into telomere biology, exploring how telomerase regulation and shelterin complex dynamics control cellular aging and senescence pathways.
A new Nature Communications study reveals NONO, SFPQ, and PSPC1 proteins guide telomerase from Cajal bodies to telomeres, with their loss causing progressive telomere shortening.
A new mini review maps the most promising gene therapy targets for neurodegenerative, cardiovascular, metabolic, and eye diseases linked to aging.
ALT cancers insert centromeric DNA at telomeres, forming protective chromatin that sustains tumor survival without telomerase.
Breakthrough imaging reveals how telomerase protects chromosome ends, offering new insights into cellular aging mechanisms.
A meta-analysis of 8 RCTs finds TA-65 modestly elongates telomeres, especially in adults over 60, but doesn't translate to frailty or inflammation benefits.
TOP3A topoisomerase is essential for ALT, a telomere-maintenance pathway used by 10–15% of cancers, opening new therapeutic targets.
Modified mRNA encoding hTERT restores telomerase activity, reduces senescence, and cuts fibrosis markers in end-stage pulmonary fibrosis tissue.
Comprehensive review reveals how telomerase biogenesis regulates telomere maintenance, offering new therapeutic targets for aging disorders.
New research reveals how cancers manipulate telomeres in unexpected ways, offering fresh targets for treatment.
Dive deep into the molecular machinery of genomic instability — from telomere-driven crisis states and epigenetic remodeling at break sites to cutting-edge therapeutic strategies targeting DNA repair fidelity in aging and cancer.
