20 articles
A deep mechanistic exploration of how hypothalamic IKKฮฒ/NF-ฮบB signaling, htNSC exosomal communication, and multi-axis hormonal dysregulation drive systemic aging โ plus cutting-edge therapeutic strategies.
OSK gene therapy targeting engram neurons restored memory to youthful levels in aged mice and Alzheimer's models, reversing senescence hallmarks.
Dive into the molecular machinery behind lifelong brain health โ from BDNF-TrkB signaling cascades and adult hippocampal neurogenesis to glymphatic amyloid clearance and cutting-edge interventions including senolytics, GLP-1 agonists, and transcranial stimulation.
Breakthrough antisense therapy demonstrates sustained benefits for rare genetic form of ALS in extended clinical trial.
New research identifies FTL1 protein as key driver of brain aging. Reducing it restored memory and neural connections in mice.
Researchers combined ultrasound with gene therapy to treat Leigh syndrome, significantly extending survival in mouse models.
Go beneath the surface to explore how NF-ฮบB signaling, IKKฮฒ activation, and hypothalamic stem cell decline drive whole-body aging โ and which interventions can slow the process.
Completed study of 102 older adults tested whether combined interventions can preserve brain volume and improve mobility through muscle-brain axis.
A chromatin-remodeling gene called SMARCAD1 controls tau levels โ and switching it off could be a new therapeutic target for Alzheimer's.
Dr. Sinclair explains the cellular mechanisms of aging and shares practical strategies to activate your body's natural longevity pathways.
Personalized treatment approach targeting multiple causes of cognitive decline outperformed standard care in 9-month trial.
Dr. Rhonda Patrick reveals how sulforaphane, omega-3s, vitamin D, and magnesium trigger cellular stress responses that enhance longevity.
Scientists developed mitoDREADD-Gs, a novel tool that restores cognitive function by enhancing mitochondrial activity in mouse models of dementia.
Large 6-year study tested dietary interventions including caloric restriction and omega-3s in 330 people with mild cognitive impairment.
New research reveals how TSC2 mutations suppress translation of autism and epilepsy genes, offering potential therapeutic targets.
A new tool that boosts mitochondrial activity in neurons restored memory in dementia mice, suggesting energy failure drives Alzheimer's symptoms.
Antibody therapies show promise for preventing Alzheimer's in cognitively healthy people with disease biomarkers.
New review reveals promising tau-targeting therapies showing cognitive benefits and slowed brain pathology in Alzheimer's trials.
German researchers test whether digital environmental enrichment can boost mental and physical wellbeing in seniors through telehealth.
Boosting BNIP3 in muscle tissue extends fly lifespan and shields the brain from age-related degeneration via a muscle-brain signaling axis.
