Exercise May Supercharge Your Brain's Waste-Clearance System
New review links physical activity to glymphatic function — the brain's built-in detox network that flushes neurotoxic proteins.
20 articles
New review links physical activity to glymphatic function — the brain's built-in detox network that flushes neurotoxic proteins.
A Cochrane meta-analysis of 8 RCTs finds most pharmacological treatments fail to improve ataxia scores, though upper limb dexterity may benefit.
A landmark Nature Immunology review reveals adaptive immune cells actively shape neurodegeneration — and could be targeted therapeutically.
A Cochrane meta-analysis of 17 RCTs finds amyloid-targeting antibodies offer minimal cognitive gains while significantly raising ARIA risk.
A Cochrane review of two RCTs finds very low-certainty evidence that IGF-1 neither prevents nor worsens retinopathy of prematurity in extremely preterm infants.
A landmark review argues neurodegeneration is driven by interacting misfolded proteins, not single culprits — reshaping diagnosis and treatment.
A paradigm-shifting review proposes that α-synuclein pathology originates in the kidneys and spreads to the brain via PKC signaling.
A major Lancet review argues that optimizing current depression treatments may be more impactful than developing new ones.
A Lancet systematic review finds interactive, personalized dementia prevention programs outperform mass media campaigns in changing real-world behavior.
A new review links BPA exposure from common plastic products to key Alzheimer's mechanisms including amyloid buildup, tau pathology, and cognitive decline.
A new review reveals how dysregulated brain RAS drives Parkinson's neurodegeneration — and why ARBs and ACE inhibitors may be neuroprotective.
A landmark review reveals astrocytes as active immune players whose dysfunction drives Alzheimer's, Parkinson's, MS, and ALS.
GLP-1 receptor agonists show early promise for co-occurring substance use and mood disorders by targeting shared brain reward pathways.
A systematic review of 59 animal studies finds icariin cuts amyloid burden and boosts cognition — but major methodological gaps cloud the evidence.
A landmark review reframes astrocytes as multilayered processing units that regulate synapses, circuits, and brain function at multiple spatial scales.
A new minireview reveals early vascular aging, endothelial dysfunction, and insulin resistance may drive MS pathogenesis before disability sets in.
A 30-study review finds exercise and mindfulness alter resting brain connectivity, but the largest rigorous trial shows minimal effects.
New review reframes white matter degeneration as an active driver of Alzheimer's, not just collateral damage — with major diagnostic and treatment implications.
A new framework warns that AI tools used too early in medical education may prevent trainees from developing core clinical reasoning skills.
A Lancet review reveals stroke pathways fail to adequately address frailty, disability, and comorbidity — gaps with major consequences for older patients.