20 articles
A Cochrane meta-analysis of 8 RCTs finds most pharmacological treatments fail to improve ataxia scores, though upper limb dexterity may benefit.
A 30-study review finds exercise and mindfulness alter resting brain connectivity, but the largest rigorous trial shows minimal effects.
New review links physical activity to glymphatic function — the brain's built-in detox network that flushes neurotoxic proteins.
GLP-1 receptor agonists show early promise for co-occurring substance use and mood disorders by targeting shared brain reward pathways.
A new minireview reveals early vascular aging, endothelial dysfunction, and insulin resistance may drive MS pathogenesis before disability sets in.
A Lancet systematic review finds interactive, personalized dementia prevention programs outperform mass media campaigns in changing real-world behavior.
A Cochrane meta-analysis of 17 RCTs finds amyloid-targeting antibodies offer minimal cognitive gains while significantly raising ARIA risk.
An expert panel maps the pathways linking urban greenspace to Alzheimer's risk and offers researchers a standardized measurement playbook.
A landmark Nature Immunology review reveals adaptive immune cells actively shape neurodegeneration — and could be targeted therapeutically.
A landmark review reveals astrocytes as active immune players whose dysfunction drives Alzheimer's, Parkinson's, MS, and ALS.
A computational review reveals how neural timescales link brain structure, dynamics, and cognition — with implications for brain health.
A landmark review reframes astrocytes as multilayered processing units that regulate synapses, circuits, and brain function at multiple spatial scales.
A Cochrane review of two RCTs finds very low-certainty evidence that IGF-1 neither prevents nor worsens retinopathy of prematurity in extremely preterm infants.
A major Lancet review argues that optimizing current depression treatments may be more impactful than developing new ones.
A Lancet review reveals stroke pathways fail to adequately address frailty, disability, and comorbidity — gaps with major consequences for older patients.
A new framework warns that AI tools used too early in medical education may prevent trainees from developing core clinical reasoning skills.
A landmark review argues neurodegeneration is driven by interacting misfolded proteins, not single culprits — reshaping diagnosis and treatment.
A paradigm-shifting review proposes that α-synuclein pathology originates in the kidneys and spreads to the brain via PKC signaling.
A narrative review reveals India's unique dementia risk profile — and why Western findings may not apply to 1.4 billion people.
A new review links BPA exposure from common plastic products to key Alzheimer's mechanisms including amyloid buildup, tau pathology, and cognitive decline.
