Pig-to-Human Organ Transplants Edge Closer to Clinical Reality
After 120 years of failed attempts, genetic engineering is finally making xenotransplantation viable. Here's where the science stands.
20 articles
After 120 years of failed attempts, genetic engineering is finally making xenotransplantation viable. Here's where the science stands.
New review explores how artificial intelligence, pig organs, and regenerative medicine may solve the organ shortage crisis.
A dual human-primate trial finds donor MSC infusions are safe but do not establish chimerism or tolerance, and may trigger rejection-causing antibodies.
Review explores how transplant medications affect cellular communication particles that trigger immune rejection responses.
Study reveals regional microbiome mismatches from FMT can lead to persistent off-target effects on metabolism and immunity.
Transplant recipients face dramatically higher cancer rates, especially skin and virus-linked tumors, requiring intensive surveillance.
A novel dual CAR T-cell approach eliminated blocking antibodies in highly sensitized patients, enabling kidney transplants previously considered impossible.
Scientists pinpoint a hyperactivated neutrophil subtype fueling lung transplant damage and show a mitochondrial inhibitor can block it.
3D cardiac cell clusters survive better than single cells when transplanted into pig hearts after myocardial infarction.
LyGenesis wins funding to develop immune tolerance for pancreatic islet transplants, using its novel lymph node organ-growing platform.
United Therapeutics wins FDA approval for LungFX, a device that keeps donor lungs viable outside the body for transplant reassessment.
A new perspective outlines how stem cells, bioprinted organs, and cross-species genes could replace — not just repair — aging biology.
Sana Biotechnology's hypoimmune cell therapy may eliminate the need for lifelong immunosuppression in type 1 diabetes transplants.
New breakthrough allows immune cells to be reprogrammed inside patients, potentially making cancer immunotherapy safer and more accessible.
Scientists eliminated mitochondria from stem cells and embryos using enforced mitophagy, uncovering how mitochondrial DNA shapes development and species identity.
A landmark 2025 review details how stem cell–derived beta cells and refined islet transplants are transforming T1D treatment, moving toward immunosuppression-free therapy.
Tregzi slashes chronic graft-versus-host disease rates from 44% to 12.6%, offering new hope for stem cell transplant patients.
A new method co-differentiates mesoderm and endoderm in a single spheroid, producing organoids with organ-specific blood vessels that integrate with host circulation.
Gene therapy transforms liver macrophages into cancer-fighting cells that restore exhausted T cells and eliminate metastases.
A new iPSC method simultaneously activates two transcription factors to grow perfusable vascular organoids in 5 days, outpacing prior 3-week protocols.