9 articles
Dive deep into partial reprogramming, niche remodeling, senolytics, and cutting-edge clinical therapies — the molecular toolkit for reversing stem cell aging.
A rigorous mechanistic deep-dive into the molecular logic of partial reprogramming — from chromatin dynamics and epigenetic clock reversal to in vivo delivery strategies, oncogenic risks, and the path to clinical translation.
Go beyond the basics and explore the precise molecular mechanisms by which Yamanaka factors remodel the epigenome, silence cell identity, and unlock pluripotency — with implications for partial reprogramming therapies.
Discover how four tiny proteins can turn back the clock on aging cells — and what this means for the future of medicine and longevity.
Activating three Yamanaka factors — OCT4, SOX2, and KLF4 — appears to reverse epigenetic aging in human eye cells, marking a milestone in rejuvenation medicine.
Researchers propose using partial reprogramming to rejuvenate donor organs outside the body before transplantation.
Researchers identify methods to induce powerful regenerative cell clusters in mammals using temporary pluripotency factors.
Japanese researchers develop minimally invasive method to transform T cells into glutamatergic neurons using just 5 factors.
The father of induced pluripotent stem cells discusses regenerative medicine milestones and future therapeutic potential.
