20 articles
A comprehensive review maps every major in vitro aging model—from Hayflick's fibroblasts to iPSCs—and the interventions that reverse cellular aging.
A 2025 narrative review maps how regenerative medicine, epigenetics, AI, and microbiome science are transforming cosmetic dermatology.
Dive deep into partial reprogramming, niche remodeling, senolytics, and cutting-edge clinical therapies — the molecular toolkit for reversing stem cell aging.
Scientists used three Yamanaka factors to help mouse heart muscle cells complete division, reducing scar tissue after heart attacks.
A rigorous mechanistic deep-dive into the molecular logic of partial reprogramming — from chromatin dynamics and epigenetic clock reversal to in vivo delivery strategies, oncogenic risks, and the path to clinical translation.
Go beyond the basics and explore the precise molecular mechanisms by which Yamanaka factors remodel the epigenome, silence cell identity, and unlock pluripotency — with implications for partial reprogramming therapies.
Discover how four tiny proteins can turn back the clock on aging cells — and what this means for the future of medicine and longevity.
Activating three Yamanaka factors — OCT4, SOX2, and KLF4 — appears to reverse epigenetic aging in human eye cells, marking a milestone in rejuvenation medicine.
Scientists demonstrate how brief activation of cellular reprogramming factors can rejuvenate aged organs and restore regenerative capacity safely.
Revolutionary approach using Yamanaka factors shows promise for restoring youthful function to aging retinal cells and treating blindness.
Placental stem cell vesicles containing microRNAs reactivate aging neural cells through OSKM transcription factors.
New study reveals why promising chemical cocktails for cellular rejuvenation fail in living mice - dangerous fat accumulation.
Researchers propose using partial reprogramming to rejuvenate donor organs outside the body before transplantation.
Researchers identify methods to induce powerful regenerative cell clusters in mammals using temporary pluripotency factors.
Scientists discover how reprogramming factors rejuvenate eye cells and restore vision by activating a protective enzyme that clears toxic lipids.
Japanese researchers develop minimally invasive method to transform T cells into glutamatergic neurons using just 5 factors.
New research reveals how cellular identity loss accelerates aging and disease, but Yamanaka factors can reverse this process.
New research using extreme value theory suggests human aging may plateau at 110, making lifespan theoretically unlimited but practically short.
Researchers developed a method to artificially age stem cells, creating better models for studying neurodegeneration and other age-related conditions.
New small-molecule approach offers safer alternative to genetic reprogramming for turning back the cellular clock.
