Your Organs Age at Different Rates — Multi-Omics Clocks Could Reveal Which
Not all organs age at the same pace. This review introduces a conceptual framework for organ-specific biological aging clocks that combine genomic, epigenomic, transcriptomic, proteomic, and metabolomic data into a unified multi-omics approach. Traditional single-layer biological clocks — like DNA methylation clocks — capture only one dimension of aging. By integrating multiple omics layers, researchers hope to more accurately measure how individual organs age and why some people develop age-related diseases earlier than others. The authors acknowledge that while the concept is compelling, real-world clinical implementation remains challenging due to differences across omics platforms and limited dataset availability. The review maps out current approaches and proposes strategies to close methodological gaps, laying groundwork for more robust, clinically useful aging clocks in the future.