Aging biology, lifespan extension, hallmarks of aging, and healthspan optimization
2910 articles
A 16:8 TRF regimen extended lifespan and improved gut integrity in fruit flies—without sacrificing reproductive fitness or physical activity.
A pilot trial shows a recipe-based FMD reduces body fat and IGF-1 while preserving muscle mass in breast cancer patients undergoing chemotherapy.
A 800-mouse study across 10 genetically diverse strains finds IF extended lifespan in males but not females, with outcomes heavily shaped by genetic background.
Mouse study shows FMD cycles dramatically reduce acute kidney injury and CKD progression by suppressing CCL2-driven monocyte infiltration.
Delphinidin, a natural anthocyanin, prevented microglial senescence via AMPK/SIRT1 signaling, reducing amyloid plaques and restoring cognition in AD mice.
A randomized trial shows older adults with insomnia experience dramatically greater depressive responses when exposed to inflammatory challenge.
A decade of evidence shows poly-L-lactic acid triggers collagen-rebuilding cascades, reshaping aesthetic medicine into regenerative therapy.
New research shows fructose directly programs immune T cells toward inflammatory states via mTORC1 and glutamine metabolism—and metformin reverses it.
A massive multi-omic study of 281 patients reveals that where an infection originates—lung, gut, or skin—drives distinct immune programs in sepsis.
Researchers used proteomics to split a hybrid liver disease into two distinct subtypes with starkly different survival and cirrhosis outcomes.
A landmark meta-analysis shows aerobic, combined, and HIIT training all significantly reduce ambulatory blood pressure — a stronger mortality predictor.
New POTOMAC trial data show adding durvalumab immunotherapy to standard BCG treatment significantly reduces high-risk bladder cancer recurrence.
