Aging biology, lifespan extension, hallmarks of aging, and healthspan optimization
2910 articles
A lysosome-to-epigenome pathway in C. elegans extends lifespan across multiple generations via histone H3.3 transport from gut to germline.
New research reveals how when you eat reshapes adipocyte signaling to boost endurance — and identifies a druggable target to mimic the effect.
A new study reveals that too much or too little Wnt signaling disrupts cilia formation, with mTOR inhibition rescuing the defect.
A 2026 review maps the molecular architecture of telomerase across four model organisms, illuminating cancer and aging disease mechanisms.
Middle-aged marathon runners showed 2.06-fold higher hTERT expression and significant cardiac adaptations compared to inactive controls.
Scientists find bowhead whale cells repair DNA damage faster and more accurately than other mammals, offering clues to extreme longevity.
Single-cell and spatial transcriptomics reveal how excess iron triggers cellular senescence and metabolic dysfunction in ovarian follicles, explaining poor oocyte quality in endometriosis.
A landmark multi-omic study of 300+ adults reveals non-linear T cell reprogramming and TH2 bias in midlife that blunts vaccine responses.
A new bioenergetic framework reframes aging and disease as consequences of excess cellular energy resistance in biological circuits.
A randomized trial found moderate-to-vigorous exercise reduced brain-predicted age gap by ~1 year in adults aged 26–58.
A landmark study integrating genome, methylome, transcriptome, and proteome data from 1,000+ participants reveals five master exercise genes in muscle.
A landmark study finds muscle mitochondrial respiration and cardiorespiratory fitness—not just socioeconomic factors—explain slower walking speeds in older Black adults.
