Single Molecule Activates Five Receptors to Target Obesity and Metabolic Disease
A novel conjugate merges GLP-1/GIP incretin signaling with pan-PPAR activation in one molecule, potentially revolutionizing metabolic therapy.
Insulin resistance, blood sugar regulation, metabolic syndrome, and body composition
350 articles
A novel conjugate merges GLP-1/GIP incretin signaling with pan-PPAR activation in one molecule, potentially revolutionizing metabolic therapy.
Discover AMPK — the master switch inside your cells that monitors energy levels and triggers powerful anti-aging responses when activated.
Super-resolution microscopy reveals how mitochondrial mRNAs are distributed, folded, and released during apoptosis inside living cells.
Maastricht University investigated whether NA, NAM, and tryptophan together could restore mitochondrial function in physically compromised older adults.
Six leading CGM platforms compared on accuracy, evidence quality, and longevity claims — most fall short of the hype.
Early bile acid and incretin responses after duodeno-ileal diversion may forecast long-term glycaemic outcomes in metabolic disease.
Men with T2D showed significantly greater postural instability after exercising in humid heat, despite normal thermoregulatory responses.
Combining cold exposure with exercise activates a key metabolic pathway to reduce liver fat and fibrosis more effectively than either intervention alone.
New findings suggest genetic variants could explain why some patients lose more weight on semaglutide or tirzepatide — and why others suffer more side effects.
Continuous glucose monitors are popular in biohacking circles, but direct evidence linking CGM use to extended lifespan remains thin.
Huberman breaks down the neuroscience of sugar desire and shares practical tools to regulate blood glucose and curb cravings.
A deep mechanistic exploration of how ectopic lipid accumulation, mitochondrial dysfunction, mTOR-IRS1 feedback, and inflammatory crosstalk converge to drive age-related insulin resistance — plus emerging therapeutic strategies.