Stem cells, exosomes, gene therapy, peptides, hyperbaric oxygen, and epigenetic reprogramming
415 articles
Dasatinib + quercetin clears senescent kidney cells, restores anti-aging protein Klotho, and reverses transcriptional aging across multiple renal cell types.
Adding a vascular network to stem cell-derived islet organoids dramatically improves beta-cell calcium signaling, insulin secretion, and diabetes reversal in mice.
Biomolecular condensates formed by liquid-liquid phase separation offer a new platform for clearing disease-causing proteins conventional drugs can't target.
A short-term drug combo rejuvenates aged mesenchymal stem cells, boosting proliferation and reducing inflammatory markers in vitro.
A new review maps how blood stem cell metabolism shifts with aging and how leukemia hijacks those changes — pointing to targeted therapeutic strategies.
A new review traces how aging science evolved from single-cause theories to partial reprogramming with Yamanaka factors as a lifespan-extending strategy.
Master the cutting-edge molecular pharmacology of Wnt pathway modulation — from small-molecule β-catenin activators to senescence-driven inhibitor networks — and understand how researchers are translating these mechanisms into regenerative therapies.
A 260-infant RCT tests whether adding bleomycin injections to low-dose propranolol accelerates hemangioma regression and improves skin outcomes.
Senescent endothelial cells that accumulate after bone injury sabotage stem cell repair — and quercetin delivered locally can reverse this.
A new mitochondrial epigenetic editor silences aging-linked genes without altering DNA sequence, opening doors to programmable longevity interventions.
Go beyond the basics to understand how Wnt ligands, receptor complexes, and beta-catenin destruction machinery orchestrate stem cell behavior — and why these mechanisms break down with age.
With brensocatib now approved, researchers are mapping the next wave of therapies for this chronic, underserved lung disease.
