Stem cells, exosomes, gene therapy, peptides, hyperbaric oxygen, and epigenetic reprogramming
415 articles
Human umbilical cord stem cell exosomes carrying Let-7 microRNAs restored hair growth in mice and increased hair density in a clinical trial.
A pharmacological cocktail transiently activates reprogramming genes in senescent endothelial cells, restoring function and improving blood flow in aged mice.
Discover how a remarkable biological 'on/off switch' controls your body's ability to regenerate tissues — and why it tends to get stuck as we age.
A novel bone-mimicking scaffold delivering low-dose rhBMP-2 achieved complete fracture union in 4 months in a medically complex elderly patient.
A landmark effort to bank immune-compatible stem cells matched to the majority of the US population — now terminated.
A phase 1 dose-escalation trial tests the safety of AAV-delivered ND4 gene therapy in patients with Leber's hereditary optic neuropathy.
NHLBI researchers optimize collection and storage of umbilical cord blood from sickle cell-affected and healthy newborns for future stem cell therapies.
A comprehensive review of keratoprosthesis devices and bioengineered corneal therapies offering hope for end-stage corneal blindness.
Stem cell-derived fibroblasts partially adopt organ-specific transcriptional profiles when co-cultured with heart, skin, gut, or lung cells — with key implications for disease modelling.
A comprehensive review of cell-based therapies and engineered biomaterials for SCI, covering ESCs, MSCs, NSCs, and scaffold strategies.
A Phase 1/2 trial of NFS-02 gene therapy for LHON-associated vision loss was terminated before completion, raising questions about mitochondrial gene therapy.
Phase 3 data show exa-cel eliminated transfusions and vaso-occlusive crises in children ages 5–11 with serious inherited blood disorders.
