JAK Inhibitor Tofacitinib Shows Promise Against Rheumatoid Arthritis in Phase 3 Trial
Pfizer's oral JAK inhibitor demonstrated efficacy comparable to adalimumab for treating moderate to severe rheumatoid arthritis.
Autoimmune diseases, immune modulation, inflammation, and self-tolerance
203 articles
Pfizer's oral JAK inhibitor demonstrated efficacy comparable to adalimumab for treating moderate to severe rheumatoid arthritis.
New research reveals how RA affects muscle biomechanics within 6 months of symptom onset, offering insights for early intervention.
Large Hong Kong registry study tracked how well patients stayed on newer JAK inhibitors versus traditional TNF blockers for RA treatment.
Scientists identify key mechanism that determines why some immune thrombocytopenia patients maintain remission after stopping treatment.
Revolutionary cancer treatment adapted for autoimmune diseases achieves drug-free remission in lupus trials, with RA applications emerging.
Researchers outline the scientific roadmap needed to cure autoimmunity without lifelong immunosuppressive drugs.
Local hormone system in joints fuels rheumatoid arthritis and osteoarthritis through distinct inflammatory pathways.
New study finds JAK inhibitors are as safe as other RA treatments for reproductive health in women of childbearing age.
New research reveals intermittent fasting forces immune memory cells from their protective niches, potentially compromising long-term immunity.
Researchers modified NK and T cells with special receptors that help them track down and infiltrate solid tumors more effectively.
New research reveals how helper T cells become highly destructive in joints, offering potential therapeutic targets for autoimmune arthritis.
Scientists discover how immune cells work together in unexpected ways, opening new paths for cancer therapy and transplant success.