Vitamin D Analog Paricalcitol Boosts Chemotherapy in Pancreatic Cancer Trial
A phase 1 study finds paricalcitol combined with chemotherapy shows early promise against metastatic pancreatic cancer.
Latest breakthroughs in cancer research, treatment, and prevention
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A phase 1 study finds paricalcitol combined with chemotherapy shows early promise against metastatic pancreatic cancer.
A Dana-Farber/Broad Institute study links glioblastoma transcriptional states to survival outcomes in patients receiving immune checkpoint blockade.
A newly identified macrophage-Treg axis in tumor-draining lymph nodes may explain how colorectal cancer evades immune attack.
Cell publishes a tribute to Gregory J. Hannon, whose landmark work on RNAi and piRNA pathways reshaped cancer biology and gene regulation.
A newly discovered hepatic micropeptide suppresses liver cancer progression by jamming a key mitochondrial RNA processing complex.
New research reveals that whole-genome doubling triggers epigenetic changes that silence antigen presentation, letting tumors evade CD8+ T cells.
MIT researchers identify oncofetal cell states in colorectal tumors that mimic embryonic intestines and prime cancer cells for invasion.
A newly identified molecule called SLAMF6 exhausts cancer-fighting T cells from within — and blocking it may revive failed immunotherapies.
A small molecule called UNI418 shuts down cancer cells' DNA repair machinery, making drug-resistant tumors vulnerable to treatment again.
A comprehensive review reveals how the senescence secretome suppresses tumors early but drives progression, resistance, and metastasis chronically.
Scientists discover that 3' UTRs of mRNAs actively guide protein folding during translation, controlling activity of key cancer and aging regulators.
A new commentary in Gut raises important concerns about using large language models to detect colorectal polyps in endoscopic images.