Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1290 articles
Scarlet Therapeutics grows universal red blood cells that survive as long as donated ones, opening a path to engineered therapeutic blood.
A landmark multi-omic study shows GLP-1 receptor agonists like semaglutide broadly reverse age-related molecular changes in aging mice.
Senescent cells leak mitochondrial RNA into the cytosol, triggering an antiviral response that fuels the inflammatory SASP and age-related disease.
Adult-onset adipocyte FGF21 overexpression extends lifespan up to 3.3 years in high-fat-diet mice, cutting inflammation and toxic lipids.
A large Chinese cohort study finds that higher psychological frailty scores strongly and linearly predict incident stroke, independent of traditional risk factors.
A new Gompertz-based algorithm converts standard clinical biomarkers into a biological age estimate that predicts mortality, frailty, and chronic disease risk.
A new composite index blending lipid dysregulation and frailty predicts CVD, stroke, and heart disease with striking accuracy over 9 years.
A 7-year Chinese cohort study finds that higher frailty scores and accelerated biological aging independently and jointly predict new COPD diagnoses.
Scientists trace age-related memory loss to gut bacteria that inflame nerves, silencing the gut-brain axis and crippling hippocampal memory formation.
A gut-derived metabolite called phenylacetic acid rises with age and causes blood vessel cells to senesce, linking the microbiome to cardiovascular aging.
Dysfunctional meningeal lymphatics disrupt cortical E/I balance through microglia-driven IL-6 signaling — and restoring them reverses aging-related cognitive decline.
Researchers critically reassess 13 years of glymphatic research and find no confirmed causal link to Alzheimer's disease in humans yet.
