Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1290 articles
Researchers identify four senescence-enriched vascular cell clusters in atherosclerotic mouse aortas and derive a conserved transcriptomic signature including Spp1, Ctsb, and Tnfrsf11b.
Traditional kidney-tonifying formulas ZGP and YGP extend C. elegans lifespan via kaempferol-driven mitophagy, revealing a molecular mechanism behind TCM anti-aging effects.
Researchers built MoveIt! Age, a wearable-only biological age clock using daily step data that outperforms blood tests in predicting frailty and mortality.
A new Nature Communications study reveals NONO, SFPQ, and PSPC1 proteins guide telomerase from Cajal bodies to telomeres, with their loss causing progressive telomere shortening.
A comprehensive review of in vitro assays for inducing cellular senescence and screening senolytic drugs, highlighting key challenges in clinical translation.
Fucoidan, dasatinib+quercetin, and MitoQ each counteract hyperoxia-driven cellular senescence in fetal airway cells via distinct mechanisms.
A systematic review reveals quercetin's multi-pathway mechanisms in combating ovarian aging, PCOS, premature ovarian insufficiency, and chemo-induced damage.
A sweeping 2025 review maps how the plant compound quercetin combats cardiovascular disease, dementia, osteoporosis, and more at the molecular level.
New research shows psilocybin boosts survival in aged mice by 30% and extends human cell lifespan up to 57% in lab studies.
Researchers built an aging clock from wrist PPG wearable data of 213,000+ people, linking biological age gap to heart disease, diabetes, and behavior.
A single dose of TERT circular RNA reverses hallmarks of vascular senescence more powerfully and durably than standard mRNA in progeria endothelial cells.
New research shows that reduced FTO expression drives granulosa cell senescence, cutting fertility-related hormone output and accelerating ovarian aging.
