Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1290 articles
A longitudinal mouse study identifies sex-specific plasma metabolite biomarkers of frailty, pointing to B vitamins in females and lipids in males.
A 2025 review maps how quercetin fights senescence, oxidative stress, and inflammation in AMD, cataract, diabetic retinopathy, and glaucoma.
A randomized trial finds quercetin reduces vascular senescence and inflammation in male CAD patients undergoing bypass surgery, with no benefit in females.
Contrary to expectations, breeding boobies elongated their telomeres during incubation — suggesting individual quality drives telomere dynamics.
A comprehensive review reveals fisetin's broad therapeutic potential spanning senescence, neurodegeneration, and cancer — with key bioavailability hurdles to overcome.
A new metabolic immune mechanism lets the gut starve intracellular bacteria that antibiotics can't reach — with implications for microbiome and aging.
New research shows PINK1 overexpression suppresses chondrocyte senescence by inhibiting p38 MAPK/NF-κB signaling, offering a mitochondria-targeted OA therapy.
New C. elegans research reveals metformin interacts with mitochondrial and ER stress pathways in complex, context-dependent ways that alter longevity.
Buck Institute scientist engineers CAR-Treg cells to detect amyloid plaques and release Alzheimer's antibody exactly where needed.
A Japanese study of 495 centenarians finds elevated NfL blood levels strongly linked to worse cognition and 36% higher mortality risk.
New mouse research reveals how intestinal aging creates a feedback loop of inflammation, barrier breakdown, and microbiome decline.
A new startup aims to fix mRNA's biggest flaw — short duration — opening doors to immune and inflammation control across a lifetime.
