Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,805 articles
Age-related loss of α2,6-sialic acid on T cells impairs immune responses to infection and cancer, with PD-1 blockade partially rescuing function.
A 2025 review reveals how neurotoxins and dermal fillers can effectively reverse age-related changes around the mouth with minimal downtime.
Human umbilical cord stem cells release HGF to redirect STAT3 into mitochondria, clearing copper buildup and restoring respiratory function after acute kidney injury.
Synthetic biology transforms yeast into factories for beta-carotene, astaxanthin, and retinol — potent antioxidants with anti-aging potential.
Splicing factor mutations rescue blood stem cells from telomere shortening, revealing a new mechanism linking aging, clonal hematopoiesis, and leukemia risk.
New metabolomics research shows taurine supplementation restores energy production, antioxidant defenses, and amino acid metabolism in aging oocytes.
A 12-week collagen tripeptide supplement reduced oxidative damage, improved insulin sensitivity, and activated a key energy-sensing enzyme in aged mice.
Dissect the deep mechanistic links between circadian clock machinery and longevity — from BMAL1 cistrome remodeling to chronopharmacology strategies that may slow biological aging.
Preclinical mouse data suggests semaglutide cycling may trigger sarcopenia in later life, raising questions about long-term body composition effects.
A Nature Aging study finds the world's longest-lived populations gained only 6.5 years of life expectancy since 1990, signaling diminishing returns.
New research from Columbia University shows time-restricted feeding improves mouse healthspan, spotlighting meal timing as a powerful longevity lever.
A new study finds insomnia patients show significantly shorter telomeres than those with RLS or sleep apnea, hinting at accelerated cellular aging.
