Longevity & Aging
Metformin Fights Vascular Aging Beyond Blood Sugar Control
A 2025 review reveals metformin's multi-pathway potential to slow arterial aging, reduce stiffness, and protect the heart.
Research Paper
May 24, 2026 0
Topic
Reversing Aging
Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,809 articles
Longevity & Aging
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PI3K Signaling: The Molecular Machinery Behind Cellular Aging
Go beneath the surface of the PI3K pathway to understand how phospholipid messengers, kinase cascades, and feedback loops shape the balance between growth and longevity.
TutorialIntermediate
May 24, 2026 0
Longevity & Aging
Frailty Accelerates in Bursts That Predict Death and Hospitalization
A study of 1.1 million adults shows frailty deficits accumulate in sudden bursts—and these episodes signal sharply higher risk of death and hospitalization.
Research Paper
May 24, 2026 0
Longevity & Aging
Mitochondria-Targeted Drugs Open New Frontiers Against Brain Aging
A comprehensive review maps the key drug strategies targeting mitochondrial dysfunction in aging and neurodegenerative diseases.
Research Paper
May 23, 2026 0
Longevity & Aging
Elamipretide Reverses Heart and Muscle Aging Without Resetting the Biological Clock
A mitochondria-targeting peptide restores cardiac and skeletal muscle function in aging mice—but leaves epigenetic and transcriptomic age unchanged.
Research Paper
May 23, 2026 0
Longevity & Aging
Senescent Heart Cells Recruit Killer Immune Cells After Heart Attack via CCL8
P16+ senescent fibroblasts and macrophages hijack immune signaling post-infarction, driving deadly cardiac remodeling through a newly identified CCL8 pathway.
Research Paper
May 23, 2026 0
Longevity & Aging
DLK1 Blocks Muscle Aging Receptor ACVR2B, Not Notch as Long Believed
A crystal structure reveals DLK1 mimics TGF-β ligands to block myostatin signaling, reshaping our understanding of muscle development.
Research Paper
May 23, 2026 0
Longevity & Aging
GLP-1 Drugs Shrink Fat but Also Muscle — New Strategies to Protect Lean Mass
Semaglutide loses ~45% lean mass per kg lost vs. 25% for tirzepatide. Experts weigh interventions to protect muscle in aging patients.
Research Paper
May 23, 2026 0
Longevity & Aging
Longer Telomeres Causally Linked to Lower Alzheimer's Risk Through Brain Changes
Mendelian randomization reveals longer telomeres reduce Alzheimer's risk by 16%, with nine brain structural changes partially explaining the link.
Research Paper
May 23, 2026 0
Longevity & Aging
How Your Body Clock Protein CLOCK Controls Aging and Cancer
The circadian CLOCK protein plays a dual role in cellular senescence — supporting healthy aging in normal cells while enabling tumor growth when hijacked.
Research Paper
May 23, 2026 0
Longevity & Aging
Key Enzyme TOP3A Found to Control Cancer's Telomere Survival Trick
TOP3A topoisomerase is essential for ALT, a telomere-maintenance pathway used by 10–15% of cancers, opening new therapeutic targets.
Research Paper
May 23, 2026 0
Longevity & Aging
Rapamycin Shrinks the Thymus Then Drives It to Rebound Beyond Baseline
Short-term rapamycin causes temporary thymic involution, then triggers regeneration exceeding baseline — hinting at immune rejuvenation as a longevity mechanism.
Research Paper
May 23, 2026 0