Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,811 articles
A massive single-cell study of 387,762 cells uncovers how thymic aging disrupts T cell development and reshapes peripheral immune function.
New research links exercise-driven upregulation of HMGCR to improved cardiac function and longer lifespan in aging Drosophila models.
A systematic review finds N-acetylcysteine improves muscle force and reduces oxidative stress—mostly in animals. Human trials are urgently needed.
Arsenic disrupts sirtuins — key NAD⁺-dependent longevity enzymes — accelerating aging and disease. New research maps the damage and points to fixes.
A 1.6-million-person cohort study finds metformin neither prevents AMD development nor slows progression to advanced disease stages.
UCL scientists propose early-life damage stays hidden until aging weakens the body's defenses, triggering diseases decades later.
A 20,000-person study validates IgG glycans as aging biomarkers, with therapeutic plasma exchange reducing glycan age by 0.4 years per month.
A new global report finds longevity clinics are scaling fast but lack the standardized frameworks needed to validate their outcomes.
Scientists discover axolotls regenerate a complete thymus from scratch, revealing midkine signaling as a key early driver with implications for reversing immune aging.
A study of 4,260 health enthusiasts found delayed-release calcium-AKG was associated with measurably younger epigenetic age.
A natural flavonoid delivered via injectable hydrogel suppresses senescence pathways in tendon stem cells, dramatically improving aged tendon healing.
Researchers built a quantitative model of IgG N-glycosylation that pinpoints a key enzyme declining with age across two Croatian cohorts.
