Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,811 articles
A new study shows ferroptosis drives cellular senescence, and blocking it with ferrostatin-1 extends lifespan and healthspan in worms and aging mice.
GH drops sharply as we age, mimicking deficiency states — yet boosting it in older adults shows mixed results and real risks.
A longitudinal study of 54 adults finds COVID-19 infection significantly accelerates biological aging across multiple epigenetic clocks.
A new mouse study shows fisetin senolytic treatment reverses age-related endothelial dysfunction by eliminating senescent cells and reducing the SASP factor CXCL12.
Fisetin encapsulated in liposomes significantly reduces IL-6 and IL-8 secretion in senescent lung cells, revealing potent senomorphic but not senolytic activity.
A new review finds kaempferol, a common dietary flavonoid, acts as a senolytic agent and produces dose-dependent hormetic effects tied to aging biology.
A 2025 comprehensive review maps how the AMPK/SIRT1/PGC-1α axis controls energy balance and drives neurodegeneration, diabetes, and cardiovascular disease.
RA patients show accelerated immune aging in T cells, B cells, and myeloid cells—predating joint inflammation and directly fueling autoimmunity.
A completed Phase 2 trial investigates the immune mechanisms behind age-related vaccine failure in older adults.
Chronic NAD depletion causes mitochondrial DNA to escape into the cytoplasm, activating an interferon response that mimics a viral infection.
A specialized immune cell population near adipose nerves declines with age, fueling inflammaging and disrupting fat metabolism.
A comprehensive 2025 review reveals how AMPK orchestrates mitochondrial fission, mitophagy, and biogenesis to restore cellular energy homeostasis.
