Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,811 articles
A landmark mouse study challenges the dogma that NAD depletion drives muscle aging, finding near-total NAD loss leaves muscle function intact.
Spatial glycomics imaging reveals outer-arm fucosylated N-glycans as powerful prognostic markers in the most aggressive breast cancer subtype.
Alkalinized lysosomes in senescent cells trap iron, blocking ferroptosis. Restoring lysosomal acidity with EN6 reverses resistance in aging and cancer.
A landmark review reveals how iron-driven cell death in the brain links neurodegeneration, stroke, and even healthy neuronal processes.
A comprehensive 2025 review maps sarcopenia's molecular drivers and spotlights stem cells, exosomes, and precision nutrition as next-gen therapies.
A Special Issue editorial synthesizes emerging evidence on how diet, inflammation, and metabolism drive—or defend against—age-related muscle loss.
A 21,000-person imaging study reveals visceral fat, liver fat, and muscle fat infiltration accelerate cardiovascular ageing differently by sex.
A single IV dose of TERT mRNA-loaded lipid nanoparticles reduced microglial activation and pro-inflammatory cytokines in a mouse TBI model.
Modified mRNA encoding hTERT restores telomerase activity, reduces senescence, and cuts fibrosis markers in end-stage pulmonary fibrosis tissue.
A 2025 narrative review maps the molecular crosstalk behind exercise's systemic anti-aging effects across the brain–muscle–liver axis.
A systematic review of 13 studies maps distinct trajectory patterns of intrinsic capacity in aging adults and identifies key risk factors.
A three-nation cohort study finds eCRF protects against depression in Western older adults but shows the opposite signal in China.
