Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1288 articles
A lysosome-to-epigenome pathway in C. elegans extends lifespan across multiple generations via histone H3.3 transport from gut to germline.
A 2026 review maps the molecular architecture of telomerase across four model organisms, illuminating cancer and aging disease mechanisms.
Middle-aged marathon runners showed 2.06-fold higher hTERT expression and significant cardiac adaptations compared to inactive controls.
Scientists find bowhead whale cells repair DNA damage faster and more accurately than other mammals, offering clues to extreme longevity.
Single-cell and spatial transcriptomics reveal how excess iron triggers cellular senescence and metabolic dysfunction in ovarian follicles, explaining poor oocyte quality in endometriosis.
A landmark multi-omic study of 300+ adults reveals non-linear T cell reprogramming and TH2 bias in midlife that blunts vaccine responses.
A new bioenergetic framework reframes aging and disease as consequences of excess cellular energy resistance in biological circuits.
A randomized trial found moderate-to-vigorous exercise reduced brain-predicted age gap by ~1 year in adults aged 26–58.
A landmark study finds muscle mitochondrial respiration and cardiorespiratory fitness—not just socioeconomic factors—explain slower walking speeds in older Black adults.
A 16:8 TRF regimen extended lifespan and improved gut integrity in fruit flies—without sacrificing reproductive fitness or physical activity.
A 800-mouse study across 10 genetically diverse strains finds IF extended lifespan in males but not females, with outcomes heavily shaped by genetic background.
Delphinidin, a natural anthocyanin, prevented microglial senescence via AMPK/SIRT1 signaling, reducing amyloid plaques and restoring cognition in AD mice.
