Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1290 articles
A 800-mouse study across 10 genetically diverse strains finds IF extended lifespan in males but not females, with outcomes heavily shaped by genetic background.
Delphinidin, a natural anthocyanin, prevented microglial senescence via AMPK/SIRT1 signaling, reducing amyloid plaques and restoring cognition in AD mice.
A randomized trial shows older adults with insomnia experience dramatically greater depressive responses when exposed to inflammatory challenge.
Eric Topol and colleagues question whether blue zone longevity data is real or a statistical mirage worth rethinking.
AI4L uses 'Audit-Driven Prompting' to generate hallucination-free, evidence-based reviews of longevity therapies like senolytics and NAD+ boosters.
A comprehensive 2025 review maps the molecular and cellular mechanisms driving immune aging, from SASP to epigenetic drift.
Pre-existing immune aging signatures — not just chronological age — predict who progresses to severe COVID-19, new research shows.
A comprehensive review reveals how iron homeostasis governs brain health from infancy through old age and drives Alzheimer's and Parkinson's disease.
B cell lymphoma rapidly drives young T cells into a molecular and epigenetic aged state, while truly old T cells prove strangely resistant.
A comprehensive review reveals how elamipretide binds cardiolipin in the inner mitochondrial membrane, restoring bioenergetics in aging and disease.
MOTS-c, a peptide encoded in mitochondrial DNA, declines with age and may prevent β-cell senescence to delay both type 1 and type 2 diabetes.
A 38-plex imaging study reveals how microglia shift along a continuous activation spectrum in Alzheimer's disease, with key protein changes in CA1.
