Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1290 articles
A new systematic review finds creatine linked to cognitive benefits in older adults, especially memory and attention, though high-quality trials are still needed.
A landmark Swedish cohort tracked 427 people from age 16 to 63, revealing peak fitness arrives in the 20s–30s, then fades — mirroring elite athletes.
A comprehensive review confirms that regular exercise—across all modalities—dramatically reduces chronic disease risk and extends healthspan.
Scientists identify Pannexin1 as a calcium leak channel in the ER that triggers cellular senescence and kidney scarring after acute injury.
A landmark theory proposes that tumor suppression mechanisms like cellular senescence inadvertently accelerate aging by restricting tissue renewal.
Blood stem cells lacking DNMT3A gain telomerase activity and indefinite self-renewal — revealing a non-canonical longevity mechanism in clonal aging.
New research reveals how cerebrospinal fluid transport structures at the brain–meningeal border influence neurodegeneration, immunity, and aging.
A new causal framework links immune-cell gene regulation to telomere length, facial aging, and frailty—revealing drug targets hiding in plain sight.
A landmark review reveals how skin aging and systemic biological aging drive each other — and what that means for longevity medicine.
A Princeton study finds aging dramatically alters metabolite concentrations in mice, yet surprisingly preserves the major fluxes that drive metabolism.
A comprehensive 2025 review maps exactly how regular physical activity counteracts every major biological mechanism driving aging.
New UK Biobank data shows high cardiorespiratory and muscular fitness can offset accelerated biological aging and extend healthy lifespan.
