Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,821 articles
A comprehensive review reveals fisetin's broad therapeutic potential spanning senescence, neurodegeneration, and cancer — with key bioavailability hurdles to overcome.
A new metabolic immune mechanism lets the gut starve intracellular bacteria that antibiotics can't reach — with implications for microbiome and aging.
New research shows PINK1 overexpression suppresses chondrocyte senescence by inhibiting p38 MAPK/NF-κB signaling, offering a mitochondria-targeted OA therapy.
New C. elegans research reveals metformin interacts with mitochondrial and ER stress pathways in complex, context-dependent ways that alter longevity.
Buck Institute scientist engineers CAR-Treg cells to detect amyloid plaques and release Alzheimer's antibody exactly where needed.
A Japanese study of 495 centenarians finds elevated NfL blood levels strongly linked to worse cognition and 36% higher mortality risk.
New mouse research reveals how intestinal aging creates a feedback loop of inflammation, barrier breakdown, and microbiome decline.
A new startup aims to fix mRNA's biggest flaw — short duration — opening doors to immune and inflammation control across a lifetime.
GlycanAge's Dubrovnik conference targets translating 25 years of inflammaging research into real clinical tools for doctors and patients.
A Phase 2 pilot trial investigates whether the natural senolytic compound fisetin can reduce dysfunction and complications in COVID-19 patients.
A new proteomics atlas reveals how membraneless nuclear organelles organize gene control, stress response, and disease-linked mutations.
Scientists mapped the genome, epigenome, microbiome, metabolome, and proteome of a 117-year-old supercentenarian, uncovering what drives extreme lifespan.
