Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,821 articles
A NHANES study of nearly 5,000 adults finds higher dietary creatine intake significantly associates with lower DNA methylation-based mortality scores.
A 2025 narrative review finds creatine monohydrate supplementation safely improves muscle mass, strength, bone density, and cognition in aging populations.
A major review identifies nine common drugs—including metformin, aspirin, and dasatinib—with promising anti-aging mechanisms targeting shared biological pathways.
A silicate bioceramic outperforms dasatinib and quercetin at clearing senescent cells while simultaneously rebuilding aging bone.
A phase 1 trial of dasatinib + quercetin in 5 early AD patients uncovers fluid biomarker changes that could guide future senolytic trials.
Researchers identify NUF2 as a key driver of prostate cancer and discover fisetin, a natural compound, as a promising inhibitor of this oncogene.
Deleting the RNA methylation enzyme METTL14 in blood vessel cells reduces arterial stiffness, inflammation, and cellular senescence in mice and human cells.
A major cross-population study finds that chronic inflammation linked to aging may reflect industrialized lifestyles, not biology alone.
A major meta-analysis of 911 effect sizes finds rapamycin, but not metformin, replicates the lifespan benefits of dietary restriction in vertebrates.
Researchers reveal how chromatin fragments exit the nucleus via membrane trafficking and how metformin blocks this process to reduce age-related inflammation.
A sweeping 2025 review traces metformin from its 1922 synthesis to its emerging roles in cancer, aging, and longevity.
A rigorous mechanistic deep-dive into how hydrogen sulfide orchestrates epigenetic reprogramming, proteostasis, and inter-organ signaling — and what the latest pharmacological evidence reveals about targeting H₂S for human longevity.
