AQP4 Gene Variants Shape Parkinson's Brain Waste Clearance and Motor Decline
Specific AQP4 genetic variants alter glymphatic drainage efficiency, directly influencing motor symptom severity and progression in early Parkinson's disease.
Cognitive performance, neuroplasticity, dementia prevention, and brain aging research
794 articles
Specific AQP4 genetic variants alter glymphatic drainage efficiency, directly influencing motor symptom severity and progression in early Parkinson's disease.
New mouse study reveals aging causes region-specific neuroinflammation and perineuronal net accumulation linked to memory decline.
A landmark RCT tests whether hearing aids can protect brain health in 977 older adults over 3 years.
A landmark multicohort proteomics study reveals how APOE2 and APOE4 shape Alzheimer's risk through entirely distinct molecular mechanisms.
A completed trial tests EGCG combined with diet, exercise, and cognitive training to slow decline in ApoE4 carriers with early warning signs.
New research shows single V1 neurons in the visual cortex track internal arousal states, directly predicting perception and reaction speed.
New research reveals how the brain selectively triggers learning only during meaningful errors — not random neural noise.
A landmark Nature Neuroscience study reveals how peripheral immune cells infiltrate the spinal cord in ALS, pointing to targeted immunotherapy.
A master autophagy regulator drops with age and in AD patients — restoring it in mice clears amyloid, reduces tau, and rescues cognition.
Huberman breaks down the brain circuits behind aggression and shares evidence-based tools — sunlight, sauna, ashwagandha — to dial it down.
UC Davis scientists created novel brain-healing molecules that activate key serotonin receptors tied to neuroplasticity — without triggering hallucinations.
LINE-1 retrotransposons act as alternative gene promoters in human stem cells, and silencing them shrinks cerebral organoids.