Alzheimer's disease research, amyloid plaques, tau tangles, and cognitive decline
410 articles
A major review reveals how growth hormone and IGF-1 regulate cognition, mood, and neurodegeneration — with direct implications for aging brains.
Johns Hopkins researchers reveal how TDP-43 loss accelerates toxic tau buildup, uncovering a key mechanism in Alzheimer's and related dementias.
A new index combining brain atrophy, white matter lesions, and cognition reveals who maintains brain health with age — and who doesn't.
New research links spinal cord tau pathology to tactile deficits and cognitive impairment in Alzheimer's via disrupted CCK neurons.
A brain-penetrant compound targets a key region of TDP-43, reducing motor neuron loss and extending survival in ALS mouse models.
Two-thirds of Alzheimer cases are women. New evidence shows menopause transition—not just aging—drives that risk, opening a prevention window.
New research links multimorbidity — especially cardiometabolic disease clusters — to measurable brain-age acceleration in dementia-free older adults.
New research reveals how lipid droplets spark the protein aggregation at the heart of Parkinson's disease, disrupting energy metabolism.
Older adults with higher cardiorespiratory fitness had ~48% lower Alzheimer's risk over 8.7 years, with a clear VO2 threshold identified.
Two small clinical trials show BCG vaccination alters immune activity in cerebrospinal fluid and changes amyloid-β levels in older adults.
A Canadian RCT tests whether virtual aerobic, resistance, and cognitive training can feasibly combat mild cognitive impairment at home.
High-intensity home cycling improved ataxia symptoms, fatigue, and VO2max significantly more than dose-matched balance training over one year.
