Cilostazol Tested Against Cognitive Decline in Mild Cognitive Impairment
A Phase 2 trial explores whether cilostazol, a blood thinner with brain-protective effects, can slow memory loss in MCI patients.
Alzheimer's disease research, amyloid plaques, tau tangles, and cognitive decline
410 articles
A Phase 2 trial explores whether cilostazol, a blood thinner with brain-protective effects, can slow memory loss in MCI patients.
New research proposes delirium as the key mechanistic link explaining why severe infections dramatically raise long-term dementia risk.
When mitochondria in brain immune cells misfire, they disrupt neuronal communication and accelerate the very aging they should prevent.
A study of 991 blood metabolites finds ergothioneine has the strongest association with cognition, and antacid use may deplete it.
A streamlined mass spectrometry assay detects preclinical Alzheimer's from just 100 µL of blood with AUC 0.81 vs 0.65 for previous methods.
Researchers mapped a conserved molecular signature in motor neurons that emerges before cell death in ALS, pointing to new therapeutic targets.
A completed trial tests whether gamified museum walks can replace traditional exercise for sedentary older adults.
A new oral GLP-1 receptor agonist penetrates the brain, restoring astrocyte-neuron metabolic crosstalk disrupted in Alzheimer's disease.
Baylor scientists find tubulin redirects rogue brain proteins away from toxic aggregates, pointing to a novel neurodegenerative disease strategy.
OSK gene therapy targeting engram neurons restored memory to youthful levels in aged mice and Alzheimer's models, reversing senescence hallmarks.
A completed pilot trial tests adapted Dialectical Behavior Therapy to reduce suicidality in aging family caregivers of AD/ADRD patients.
A molecule called OLE restores microglia's protective function, reducing amyloid plaques and improving memory in animal models.