Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1290 articles
Researchers built 11 proteome-based biological age clocks from 2,448 plasma proteins across 43,000+ participants, revealing how organ-spanning data improves longevity predictions.
A sweeping 2025 review maps how mitochondrial dysfunction fuels neurodegeneration, cancer, CVD, and aging — and what emerging therapies can do about it.
A landmark mouse study challenges the dogma that NAD depletion drives muscle aging, finding near-total NAD loss leaves muscle function intact.
Spatial glycomics imaging reveals outer-arm fucosylated N-glycans as powerful prognostic markers in the most aggressive breast cancer subtype.
Alkalinized lysosomes in senescent cells trap iron, blocking ferroptosis. Restoring lysosomal acidity with EN6 reverses resistance in aging and cancer.
A landmark review reveals how iron-driven cell death in the brain links neurodegeneration, stroke, and even healthy neuronal processes.
A comprehensive 2025 review maps sarcopenia's molecular drivers and spotlights stem cells, exosomes, and precision nutrition as next-gen therapies.
A Special Issue editorial synthesizes emerging evidence on how diet, inflammation, and metabolism drive—or defend against—age-related muscle loss.
A 21,000-person imaging study reveals visceral fat, liver fat, and muscle fat infiltration accelerate cardiovascular ageing differently by sex.
A single IV dose of TERT mRNA-loaded lipid nanoparticles reduced microglial activation and pro-inflammatory cytokines in a mouse TBI model.
Modified mRNA encoding hTERT restores telomerase activity, reduces senescence, and cuts fibrosis markers in end-stage pulmonary fibrosis tissue.
A 2025 narrative review maps the molecular crosstalk behind exercise's systemic anti-aging effects across the brain–muscle–liver axis.
