Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
621 articles
Study reveals how cardiorespiratory fitness influences epigenetic aging in organ-specific ways using genetically diverse rat models.
Researchers developed imaging-based biological age clocks for seven organs that predict disease and mortality with 82% accuracy for dementia.
Large-scale study maps how different organs age at varying rates and identifies modifiable lifestyle factors that can slow organ decline.
New epigenetic clocks reveal breast cancer patients age faster in tumor tissue but slower in distant tissues like cervix.
Comprehensive review reveals EDA2R receptor as both biomarker and active driver of aging processes, offering new therapeutic targets.
Researchers developed 7 organ-specific aging clocks from MRI data, revealing molecular signatures of aging across brain, heart, liver, and other organs.
Researchers develop 2A model that tracks aging patterns across 16 organs, revealing lungs and kidneys age fastest while identifying promising drugs.
New proteomic clocks track aging in 10 organ systems, predicting mortality and disease risk with unprecedented accuracy across diverse populations.
Comprehensive review reveals how CRISPR innovations are revolutionizing genome editing with enhanced precision and safety for therapeutic applications.
New study shows physical training reduces senescent cells in skeletal muscle and improves metabolic function in both lean and obese individuals.
Scientists develop mGL392, a precision senolytic that targets aging cells using lipofuscin binding while minimizing systemic toxicity.
New review reveals senolytic therapies can both help and harm cardiovascular health, challenging clinical translation.
