Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1290 articles
A systematic review of 13 studies maps distinct trajectory patterns of intrinsic capacity in aging adults and identifies key risk factors.
A three-nation cohort study finds eCRF protects against depression in Western older adults but shows the opposite signal in China.
A landmark multi-cohort proteomics initiative links thousands of blood and CSF proteins to neurodegeneration and aging, revealing new biomarkers and drug targets.
A 44,498-person study shows brain and immune system biological age—measured from blood proteins—predict Alzheimer's risk and longevity better than genetics alone.
A landmark multi-omics study identifies betaine as a natural exercise mimetic that reduces cellular senescence and inhibits TBK1 to slow aging.
Go beyond the basics of free radicals to explore how cells decode ROS signals through specific molecular sensors, how antioxidant pathways are orchestrated, and what goes wrong in aging.
Duke researchers find that aging impairs glutamine-driven fat synthesis in muscle stem cells, limiting their repair capacity.
CD38 activity rises with age, depleting NAD+ and accelerating tissue decline. New research positions CD38 inhibitors as promising anti-aging therapeutics.
A new vaccination strategy targeting CD38 improved physical function, cognition, metabolism, and NAD+ levels in aging mice — with just a few injections.
A landmark review challenges the 'interference effect' dogma, showing concurrent resistance and endurance training can coexist and even enhance performance.
A comprehensive review reveals what nutrition strategies actually work against sarcopenia — and where critical evidence gaps remain.
Sarcopenia and osteoporosis frequently co-occur in older adults, forming osteosarcopenia — a dual threat to mobility, independence, and survival.
